The objective of present research work was to develop topical film forming solution of Clotrimazole to treat fungal infection such as athlete�s foot, jock itch and ringworm. The formulations like creams, patches, ointments used for treating these infections has various disadvantages like poor aesthetic appearance, difficulty in adhesion, repeated application. To overcome these disadvantages topical film forming solution is developed which when applied to skin, solvent evaporates and leaves a non-sticky, transparent film and it also remains intact for more than 18 h giving release of drug for prolonged period of time. Topical film forming solution is developed by using various polymers, plasticizers and penetration enhancers. The formulation was evaluated for its anti-fungal, in-vitro permeability, water vapor permeability and drug content. In-vitro anti-fungal study revealed that it has good activity compared to marketed formulation. The optimized formula containing Hydroxy propyl cellulose 6.66% showed maximum water vapor permeability compared to formulation containing Eudragit and HPC in combination. The permeability study containing no penetration enhancer showed low drug penetration of 2.66% while formulation containing oleic acid and isopropyl myristate showed 39.17% and 43.75% drug penetration respectively. From this study it can be concluded that TFFS is promising dosage form for treatment of superficial topical fungal infection.
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